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Dr. Pamela S. Mertz
Associate
Professor of Chemistry (2000)
Office: GH 208
Phone: (240) 895-4495
E-mail: psmertz@smcm.edu
Education
Camille and Henry Dreyfus Postdoctoral Fellowship,
University of Massachusetts, Dartmouth (1998-2000). Ph.D.,
Mayo Graduate School (1999).
B.A., Juniata College (1992).
Junior Year Abroad, Leeds University, Leeds,
England (1990-1991).
Courses Taught
Biochemistry I, Biochemistry II, Contemporary Chemistry,
General Chemistry I, General Chemistry II, and General Chemistry
I & II Laboratory, Topics in Chemistry, Nutrition, and Introduction
to Neuroscience.
Research/Professional Interests
My current research focuses
on a family of proteins, called the PAT family, which associates
with lipid droplets inside cells. We are interested in the functions
of the different family members and their roles in lipid metabolism
and storage.
Grants
Camille and Henry Dreyfus Supplemental
Award, 2001
Selected Publications
Sztalryd, C., Bell, M., Lu, X., Mertz, P., Hickenbottom, S., Chang,
B.-H., Chan, L, Kimmel, A.R., and Londos, C. (2006) "Functional
Compensation for Adipose Differentiation-Related Protein (ADFP)
by TIP47 in an ADFP null Embryonic Cell Line" accepted to the
Journal of Biological Chemistry, Papers in Press, 9/12/06.
Mertz, P.S, Magra, A. L., Torday, J. S., and Londos, C. (2006)
"Role of Adipose Differentiation-Related Protein in Lung Surfactant
Production: A Reassessment", accepted to the Journal of
Lipid Research, Papers in Press, 8/25/06.
Rusnak, F. and Mertz, P. (2000)
"Calcineurin: Form and Function" Physiol. Rev., 80:1483-1521.
*Hoff, R. H., Mertz, P., Rusnak, F., and Hengge,
A. C. (1999) "The Transition State of the Phosphoryl-Transfer Reaction
Catalyzed by the Lambda Ser/Thr Protein Phosphatase," J.
Am. Chem. Soc. 121:6382-6390.
Rusnak, F., Mertz, P., Reiter, T., and Yu, L.
(1999) "Regulation of the Protein Phosphatase Calcineurin by Redox:
Implications for Catalysis and Signal Transduction." In: Iron
Metabolism: Inorganic Biochemistry and Regulatory Mechanisms,
edited by Ferreira, G. C., Moura, J. J. G., and Franco, R. New York:
Wiley-VCH, p. 275-302.
Rusnak, F., Yu, L., Todorovic, S., and Mertz,
P. (1999) "The Interaction of Bacteriophage Lambda
with Mn(II): Evidence for the Formation of a [Mn(II)]2
Cluster," Biochemistry 38:6943-6952.
Mertz, P., Yu, L., Sikkink, R., and Rusnak,
F. (1997) "Kinetic and Spectroscopic Analyses of a Conserved Histidine
in the Metallophosphatases Calcineurin and Lambda Protein Phosphatase"
J. Biol. Chem. 272:21296-21302.
Rusnak, F., Yu, L., and Mertz, P. (1996) "Metalloenzymes
and Signal Transduction: the Protein Serine/Threonine Phosphatases,
a Novel Class of Binuclear Metal-Containing Enzymes" J. Biol.
Inorg. Chem. 1:388-396.
Sikkink, R., Haddy, A., MacKelvie, S., Mertz,
P., Litwiller, R., and Rusnak, F. (1995) "Calcineurin Subunit Interactions:
Mapping the Calcineurin B-Binding Domain on Calcineurin A" Biochemistry
34:8348-8356.
Wiegand, D. A., Mertz, P. S., and Latz, B. A.
(1991) "Detection of Intraoperative Laser Injury to the Facial Nerve
by Electromyographic Monitoring of Facial Muscles" Laryngoscope
101:771-774.
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