Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Brack, Cody (2011). Short- and long-term effects of gentamicin on auditory thresholds in the goldfish (Carassius auratus). (Mentor: J. Ramcharitar)
Fishes have become a popular model organism for the studying of the vertebrate auditory system. They possess inner ears similar to mammals and other vertebrates in many regards. The goldfish (Carassius auratus) is one such organism whose auditory system has been widely studied (Smith, 2006; Ramcharitar & Brack, 2010; Xiao et. Al, 2008). The goldfish was utilized in this study to investigate the damage and functional recovery of hearing due to the ototoxic drug, gentamicin. Audio evoked potentials were used to measure auditory thresholds of goldfish 7, 14, and 21 days after initial gentamicin treatment. Also, brainstem responses to a lateral line dipole stimulus were recorded using a similar technique. Significant upward shifts in auditory thresholds were observed 7 days after initial gentamicin treatment in all frequencies tested (200-800 Hz). Day 14 showed recovery on the upper and lower end of the test range. Day 21 auditory thresholds were indistinguishable from saline controls. This indicates the functional recovery of hearing with sufficient recovery time. Lateral line experiments displayed a trend of decreasing response amplitude with increasing frequency of stimulus. Amplitude of responses were much smaller above 200 Hz. Therefore, shifts in auditory threshold were most likely not affected by the lateral line system.