Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Chaudhary, Sheena (2010). Long-term Effects of Adolescent Antipsychotic Drug Treatment on Reward-related Behavior and Cognition Functioning in Adult Rats. (Mentor: A. Bailey)
Antipsychotic drugs, such as the atypical drug olanzapine, are used to treat schizophrenia and bipolar disorder. Olanzapine acts on the dopamine system and is usually administered during adolescence, when schizophrenia is typically diagnosed. However, it is unknown if drug administration during neuronal development will result in long term changes in the brain and behavior. Twenty-one Long-Evans animals were used and were treated with olanzapine during adolescence for a period of 21 days (PD28-PD49). When tested in adulthood for reward sensitivity with a progressive ratio task (PR), an FR 5choice task, and tested for cognition with a set-shifting task, control and olanzapine animals did not show significant differences in behavior. Olanzapine animals did appear to have potential differences in spatial processing as measured by the set-shifting task. However, there was a trend present indicating that olanzapine animals gave up sooner and were not as motivated for food rewards as compared to the control animals in both the PR and FR5 choice tasks.