Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Edwards, Margaret (2008). The Effect of Ongoing Adenosine Antagonism at the A1 and A2a Receptor on Long-Term Memory.
Mentor: Dr. Anne Marie Brady
The effects of chronic A1 and A2A antagonists on spatial memory were investigated. Low doses of drug were administered daily (0.3 mg/kg, i.p.) for 6 weeks. Spatial memory was assessed by performance during Morris Water Maze (MWM) training and probe tests. The results indicated that subjects that received the A1 antagonist alone tended to acquired memory slightly faster than animals that received only A2A antagonist. Animals that received A1 antagonist or a combination of the two adenosine antagonists retained spatial memory preferences longer than animals that received only the A2A antagonist. This suggest that if adenosine antagonism of the A1 receptor is minor memory is enhanced rather than impaired even when antagonism occurs over a long period of time. These findings suggest that these low levels of antagonism are enough to effect receptor activation but not enough to produce long-term changes in receptor binding.