Seminars & Events
Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.
Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195.
Friday, October 25, 2013: Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese? It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.
Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.
Hernandez, Alex (2010). The Impact Of A Four-Week Escalating Dose Regimen Of Methamphetamine On Cognition And Serotonin Levels Within The Hippocampus In Adult And Adolescent Rats. Mentor: Dr. Anne Marie Brady
Although recent rates of methamphetamine (METH) use have decreased somewhat, use remains higher among adolescents aged 12-17 than among adults 26 years or older. Exposure to METH during adolescence could result in neurological damage and psychiatric dysfunction. The current experiment focused on determining the impact of a four-week escalating dose regimen of METH, beginning in either adolescence or adulthood, on working memory, behavioral flexibility, and levels of serotonin within the hippocampus in 24 male Sprague-Dawley rats. The use of a four-week escalating dose regimen spans the entire adolescent period in rats and models the typical human pattern of METH use. Results did not support the hypothesis that all rats exposed to the escalating dose regimen of METH would show significant deficits in working memory and set-shifting, nor reductions in levels of serotonin within the hippocampus, as compared to saline controls. Results also did not support the hypothesis that adolescent-treated rats would be more susceptible to METH induced cognitive deficits and reductions in hippocampal serotonin levels as compared to adult-treated rats. Future research should utilize the escalating dose regimen and investigate the role of the HPA axis, pharmacodynamic tolerance, and chronic injection stress in METH induced cognitive deficits.