Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Holmes, Ashley (2011). Effects of orexin A in the nucleus basalis magnocellularis (nBM) on olfactory discrimination acquisition and reversal. (Mentor: A. Bailey)
The orexins or hypocretins are a family of neuropeptides found in a variety of different brain structures. The orexins produce excitatory effects and can be split into two types, orexin A (OxA) and orexin B (OxB). The orexins originate in the lateral hypothalamus but project to various other areas of the brain. Orexin interactions with the basal forebrain cholinergic system (BFCS) in particular are hypothesized to be related to arousal and attention and the BFCS is seen to be responsible for normal attentional functioning. Previous research shows that OxA plays an important role in the BFCS attention system. Therefore, we looked at the effects of OxA in an olfactory discrimination acquisition and reversal task. Results supported the hypothesis that orexin A infusions in the nBM did significantly increase attention on olfactory discrimination acquisition and reversal. Therefore, in general, rats who received OxA infusions did have an increase in attention when compared to rats given aCSF infusions.