Seminars & Events
Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.
Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195.
Friday, October 25, 2013: Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese? It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.
Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.
Ivy, David (2007). Oxidant Stress and Nicotine’s Role in Diffuse Vascular Injury.
Dr. Anne Marie Brady
The present study investigated nicotine’s role in oxidative stress and the pathogenesis of atherosclerosis in the cerebrovasculature of rats. Specifically, endothelial nitric oxide synthase (eNOS), superoxide dismutase (SOD), and nitrotyrosine levels were examined in endothelial cells (ECs) of the basilar artery to investigate the role of reactive oxygen species (ROS) in oxidative stress while proliferating cell nuclear antigen (PCNA) was examined in vascular smooth muscle cells (VSMCs) to investigate nicotine-induced promotion of atherosclerosis. This report found that nitrotyrosine levels were elevated in rats treated with nicotine and given a withdrawal period of 7 days while PCNA levels were elevated in rats treated with nicotine for 28 days. Discussed are the implications of these findings and the compensatory mechanisms of the vascular system involved in the cessation of smoking/nicotinic intake.