Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Kallevang, Jonathan (2011). Performance on hippocampal dependent tasks in the cycad model of Parkinson's disease in rats. (Mentor: A. Bailey)
The cycad model of Parkinson’s Disease (PD) has been shown to produce motor symptoms similar to that of PD, and similar to those seen in the MPTP and 6-ODHA rat models. However, unlike these previous models, cycad is a progressive and variable model that may better reflect idiopathic PD histologically. Here, cycad fed rats were subjected to hippocamal dependent tasks to observe behavioral parallels in the model that are consistent with pre-motor cognitive symptoms in human patients. We found no significant difference between cycad and control performance on the novel object recognition task, fear-conditioning, or open field analysis; illuminating the complexity of the disease pathology and interaction of multiple anatomical regions and neurotransmitter systems. Anxiety related behavior was generally observed in the cycad rats, possibly confounding our results. Also, it is possible that the highest dose of cycad ingestion in this experiment precipitated attentional deficits, but due to a small sample size, further research and experimentation is required.