Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Logan, Trevor (2008). Learning set acquisition in a rodent model of Alzheimer’s disease : the effects of continuous intracerebroventricular b-amyloid infusions on learning set . (Mentor: A. Bailey)
Endogenous b-amyloid proteins are found postmortem in the senile plaques of individuals diagnosed with Alzheimer's disease (AD). Continuous intracerebroventricular (ICV) infusion of the protein into rodent produces behavioral and anatomical changes that are associated with AD, including a degeneration of the nucleus basalis magnocelluaris (nBM) and drop in cortical cholinergic innervation. The nBM plays a critical role in the process of learning set (LS) acquisition in rodents, an ability which is associated with problem solving and higher cognitive processing. This study observed the effects of continuous ICV b-amyloid infusion on rodent LS acquisition in hopes of elucidating the connection between increased central nervous system abeta load and the changes in higher cognition. Two control tasks (open field activity and novel object recognition) were conducted to help clarify behavioral results, and brains sections were stained with Congo Red dye. The behavioral results found that neither the protein nor the vehicle group ever successfully performed above chance on trial 2 of the LS task, indicating that neither group had successful LS acquisition. However, the vehicle group did show indications of LS formation by performing above chance on trial 3 of the LS task while the abeta infused group did not, and further investigation is warranted.