Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Dippel, W. Chris (2012). Cognitive and behavioral impairments evaluated in the neonatal ventral hippocampus lesion rat model of schizophrenia. (Mentor: A.M. Brady)
The neonatal ventral hippocampus lesion (NVHL) is a proposed rat model for schizophrenia. The present study assessed the effects of the NVHL in social interaction, pre-pulse inhibition, spontaneous locomotion, response to amphetamine, set-shifting, and reversal learning. Rats with an NVHL showed deficits in pre-pulse inhibition, and set-shifting as well as a stronger response to amphetamine. Few effects were found in social interaction, and there was no effect during reversal learning. Pre-exposed rats made more perseverative errors during the set-shift task suggesting the NVHL causes impairments in PFC functioning. Percent pre-pulse inhibition was negatively correlated with trials to criterion on the shift day of the set-shifting task, response to amphetamine, and spontaneous locomotion suggesting there may be a relationship between behavior deficits elicited by the NVHL.