Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Saul, Ronald (2008). Chronic Activation of the Substantia Nigra Nociceptin/ Orphanin Receptor (NOP) Induces Motor Deficits Similar to Parkinson’s Disease: A Behavioral and Motor Assessment Following Chronic UFP-112 Administration into the SNr.
Mentor: Dr. Anne Marie Brady
In an attempt to create a working model of Parkinson’s disease that portrays the motor and non-motor features of the disorder, the nociceptin/ orphanin receptor (NOP) potent agonist UFP-112 was chronically administered into the substantia nigra pars reticulata (SNR). Previous studies have shown stimulation of the SNR NOP receptor decreases dopamine transmission along the nigrostriatal pathway and induces parkinsonian-like motor impairments (Marti et al., 2004b). Following placement of cannulas into the SNR attached to an osmotic pump containing UFP-112 or vehicle alone, both motor behaviors and non-motor behaviors were assessed. Chronic stimulation of the SNr NOP receptor system regulated the nigrostriatal pathway and induced motor performance impairments, but did not disrupt the cognitive and emotional behaviors involved with Parkinson’s disease.