Seminars & Events
Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.
Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195.
Friday, October 25, 2013: Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese? It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.
Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.
Swanson, Thomas (2011). Effect of adolescent olanzapine administration on dendritic branching in the hippocampal circuit. (Mentor: A. Bailey)
Anti-psychotic drugs are frequently prescribed to adolescents. The long-term treatment effects of these drugs are poorly understood and may be particularly dangerous in relation to the undeveloped nervous system. We investigated the effect of the atypical anti-psychotic drug olanzapine on the developing adolescent hippocampal formation in orally-treated male Long-Evans rats. Cells from both the hippocampus CA3 and dorsal dentate gyrus of each brain were digitally reconstructed and analyzed for changes in dendritic branching length and node prevalence. There were no differences in node prevalence or dendritic branch for both apical and basal portions of hippocampus CA3 neurons. No difference was observed in node prevalence in dentate gyrus granule cells. Olanzapine-treated animals had significantly greater dendritic branching length in the dentate gyrus than water-vehicle controls. We purpose the observed changes in the dentate gyrus and subsequent hippocampal circuitry provide a neuroanatomical explanation for previously observed deficits in spatial memory and concentration ability in rats treated with olanzapine during adolescence.