Seminars & Events
Monday, February 11, 2013: Dr. Daphne Soares (University of Maryland College Park) will speak on "The Sensory World of Cavefishes" at 4:45 pm in Goodpaster Hall 195.
Monday, March 4, 2013: Dr. Joe Cheer (University of Maryland Baltimore) will speak on "Endogenous Cannabinoids and the Pursuit of Reward" at 4:45 pm in Goodpaster Hall 195.
Friday, April 12, 2013: Dr. Jill McGaughy (University of New Hampshire) will speak on "The Role of Cortical Norepinephrine in the Ontogeny of Executive Function" at 3:00 pm in Schaefer Hall 106.
Dr. Erin Johnson '02 recently received her Ph.D. in Neuroscience from the University of Rochester School of Medicine, and was inducted as an alumni member of Nu Rho Psi.
Ron Saul, "Chronic activation of the substantia nigra nociceptin/orphanin receptor induces motor deficits similar to Parkinson's disease," 2008. Saul, the 2008 winner of the Neuroscience Award, infused a drug into the substantia nigra of rats and measured the resulting motor behaviors, mood disturbances, and cognitive abilities.
Whitlow, Victoria (2009). Effects of Neonatal Exposure to Antipsychotic Medication on Neuronal Expression of Glucocorticoid Receptor in the Rat Hippocampus and Medial and Orbital Prefrontal Cortices. Mentor: Dr. Aileen Bailey.
Antipsychotic medication is capable of crossing the placental barrier and is also secreted in breast milk (Miyazaki et al., 1986). Pregnant women and new mothers with schizophrenia using antipsychotic medication must therefore make the decision whether to continue treating their illness or risk abnormal neuronal development of their child. Perinatal exposure to antipsychotic medication could disrupt neuronal development and the proper organization of neuronal pathways, such as the connections of the Hypothalamic-Pituitary-Adrenal (HPA) axis and associated brain structures. The HPA axis is involved in the adaptive stress response. Activation of the HPA axis ultimately results in synthesis and secretion of glucocorticoid hormone by the adrenal cortex. Circulating glucocorticoids bind with glucocorticoid receptors (GR) in the brain and induce changes that inhibit HPA axis activity and allow for the reestablishment of homeostasis. However, abnormal neural organization of the HPA axis and associated structures could result in manifestation of neuropathology later in life. In this study, rat neonates were either exposed to daily haloperidol (8 mg/kg) or vehicle injections or were given no injections and handled only. Following in situ hybridization protocol, hippocampal subfields and two regions of the prefrontal cortex were analyzed for neuronal expression of GR in brain sections obtained once subjects reached adulthood. Significance was found only in the CA1 of the hippocampus between rats having received vehicle injections and rats that were handled only. Explanation of these unexpected results as well as possible sources or error and future directions of study are discussed.