Bailey, A. M., Kallarackal, A. J., Chen, M. , & Simard, J. M. (2006, October). Apamin significantly improves spatial cognition in a mouse model of Neurofibromatosis 1. Poster session presented at the Society for Neuroscience Annual Meeting, Atlanta, GA.

Abstract

Twenty-eight mice, 13 mice with a gene mutation for neurofibromatosis 1 (Nf1+/-) and 15 wild-type (WT) mice, were tested for spatial learning deficits in the Barnes maze.  All mice were given 16 training trials over four days and one probe trial 24 hours following training.  Nf1+/- mice showed a higher latency to the target than WT mice during spatial training trials and during the probe trial.  Results indicated impaired spatial cognitive processing in Nf1+/- mice.