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Katie Grein '13 presents her SMP

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Students can visit the College Archives (Calvert 009-ground floor) to read or view past St. Mary's Projects Mondays and Thursdays from 8 a.m. to 4 p.m. (appointments recommended).

Access to a full SMP can depend on how a student completed a release form, but most SMPs can be read or viewed in the College Archives without restriction.

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Sasha Goluskin

Goluskin, Sasha. (2012, May). Investigating the role of the 5-HT1B receptor in the CA1 of rats.
Mentor: Dr. Aileen Bailey


Previous research has shown that consolidation of spatial learning in the water maze requires the temporoammonic (TA) pathway.  The TA pathway is the neuroanatomical projection from the entorhinal cortex to the CA1 region of the hippocampus.  The CA1 contains a dense amount of serotonin (5-HT) 1B receptor mRNA.  Systemically delivered injections of a 5- HT1B antagonist have improved consolidation of spatial information in rats.  However, neuroanatomical specificity of the task is unknown.  In order to further investigate the role of the 5-HT1B receptor in CA1, bilateral injections of the 5- HT1B receptor antagonist SB216641 were directly infused into CA1 of rats via cannulae.  Subjects were given hippocampal infusions of SB216641 every other day for two weeks following 40 water maze trails.  Twenty-eight days after the initial training, subjects underwent a probe trial in the water maze to test their consolidation and retention of previous training.  It was hypothesized that infusions of the antagonist would result in an increased ability to consolidate spatial information.  Results of the study did not support the hypothesis.


Read the paper (download the pdf)