Libby Nutt Williams
Annual Colloquium - 2012
Going Viral: Thirty Years of Living with HIV/AIDS
Dr. Marjorie Robert-Guroff
National Cancer Institute
"Development of a Vaccine for HIV/AIDS: Challenges and Prospects"
Robert-Guroff will discuss reasons why developing an HIV vaccine has been so difficult, including viral integration, variability, envelope conformational structure, mutability and immune escape, and multiple routes of transmission. She describes some of the vaccine approaches that have been tried to date, reviews results of the major clinical vaccine trials that have been conducted, and summarizes where the field is at present. She incorporates some data from pre-clinical studies in the non-human primate model and discusses important areas for future research efforts in order to communicate the complexity of designing an HIV vaccine and the comprehensive approaches needed in vaccinology in general.
Dr. Robert-Guroff, Chief, Immune Biology of Retroviral Infection Section, received her Ph.D. degree from Georgetown University, and was a postdoctoral fellow of the Leukemia Society of America at the NCI, and of the Friedrich Miescher-Institut, Basel, Switzerland. She was an ASM Foundation Lecturer, and is on the editorial board of AIDS Research and Human Retroviruses. Her research interests include the biology and immunology of retroviruses, virus-cell interactions, and AIDS vaccine development.