Seminars & Events
Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.
Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195.
Friday, October 25, 2013: Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese? It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.
Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.
Bailey, A. M., Kallarackal, A. J., Chen, M. , & Simard, J. M. (2006, October). Apamin significantly improves spatial cognition in a mouse model of Neurofibromatosis 1. Poster session to be presented at the Society for Neuroscience Annual Meeting, Atlanta, GA.
Neurofibromatosis 1 (NF1) is a common genetic disorder known to cause a variety of physiological symptoms and is associated with visuospatial learning impairments. Investigations with a mouse model of neurofibromatosis 1 (Nf1) have previously found impaired long-term potentiation, a significant up-regulation of small conductance calcium activated potassium type 1 (SK1) channels, and impaired spatial learning in a water maze. We investigated possible involvement of SK1 channels in spatial learning deficits in Nf1+/- mice by administering apamin, a potent SK channel blocker, and examining performance in a water maze. Forty-four Nf1+/- mice and 41 C57BL6 (wild type, WT) mice were administered either 0.2 mg/kg apamin, 0.4 mg/kg apamin, or physiological saline through i.p. injection or micro-osmotic pumps. All mice were given 24 spatial training trials over 6 days with probe tests conducted immediately following the 4th, 12th, 20th, and 24th trials. Immediately following the final probe test, mice were given a visual test in the water maze. There were no differences between Nf1+/- and WT mice in the visual test. Nf1+/- mice treated with saline were significantly impaired in the water maze in comparison to WT mice. Both 0.2 mg/kg and 0.4 mg/kg of apamin significantly improved water maze performance in the Nf1+/- mice on the third day of training and on the corresponding probe test. The results indicate a significant improvement in spatial cognition following apamin treatment in Nf1+/- mice and a potential direction for future research regarding the learning deficits seen in NF1.